Work on the MU-2, Mitsubishi's first postwar aircraft design, began in 1956. Designed as a light twin turboprop transport suitable for a variety of civil and military roles, the MU-2 first flew on September 14, 1963. This first MU-2, and the three MU-2As built, was powered by Turbomeca Astazou turboprop.

Civil MU-2s powered by Garret engines were certified as variants of the MU-2B, using the MU-2B type followed by a number. For marketing purposes, each variant was given a suffix letter; the MU-2B-10, for example, was sold as the MU-2D, while the MU-2B-36A was marketed as the MU-2.